pI: 4.7397 |
Length (AA): 306 |
MW (Da): 34510 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_128401)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G51300 | splicing factor 1-like protein |
Babesia bovis | BBOV_IV011380 | transcription or splicing factor-like protein, putative |
Brugia malayi | Bm1_34515 | Temporarily assigned gene name protein 44 |
Candida albicans | CaO19.329 | component of the splicing commitment complex |
Candida albicans | CaO19.7961 | component of the splicing commitment complex |
Caenorhabditis elegans | CELE_Y116A8C.32 | Protein SFA-1 |
Cryptosporidium hominis | Chro.40142 | transcription or splicing factor-like protein |
Cryptosporidium parvum | cgd4_1210 | Ms15p; KH + 2 Znknuckle (C2HC) |
Dictyostelium discoideum | DDB_G0293554 | CCHC-type zinc finger-containing protein |
Drosophila melanogaster | Dmel_CG5836 | Splicing factor 1 |
Echinococcus granulosus | EgrG_000665700 | zinc finger protein |
Entamoeba histolytica | EHI_193510 | RNA-binding protein, putative |
Echinococcus multilocularis | EmuJ_000665700 | zinc finger protein |
Homo sapiens | ENSG00000168066 | splicing factor 1 |
Loa Loa (eye worm) | LOAG_00808 | hypothetical protein |
Loa Loa (eye worm) | LOAG_01156 | hypothetical protein |
Mus musculus | ENSMUSG00000024949 | splicing factor 1 |
Neospora caninum | NCLIV_057750 | hypothetical protein |
Oryza sativa | 9268114 | Os04g0385700 |
Onchocerca volvulus | OVOC7405 |
|
Plasmodium berghei | PBANKA_1122500 | conserved Plasmodium protein, unknown function |
Plasmodium falciparum | PF3D7_0623600 | transcription or splicing factor-like protein, putative |
Plasmodium knowlesi | PKNH_1126600 | conserved Plasmodium protein, unknown function |
Plasmodium vivax | PVX_114295 | hypothetical protein, conserved |
Plasmodium yoelii | PY04200 | putative transcription or splicing factor |
Saccharomyces cerevisiae | YLR116W | Msl5p |
Schistosoma japonicum | Sjp_0001760 | Splicing factor 1, putative |
Schistosoma mansoni | Smp_021540 | zinc finger protein |
Schmidtea mediterranea | mk4.002237.00 | Splicing factor 1 |
Schmidtea mediterranea | mk4.018332.00 | |
Schmidtea mediterranea | mk4.010871.01 | Splicing factor 1 |
Schmidtea mediterranea | mk4.003895.00 | Splicing factor 1 |
Toxoplasma gondii | TGME49_314860 | zinc knuckle domain-containing protein |
Theileria parva | TP01_1166 | transcription factor, putative |
Trichomonas vaginalis | TVAG_299630 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_343950 | zinc finger protein splicing factor, putative |
Trichomonas vaginalis | TVAG_293000 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_Y116A8C.32 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y116A8C.32 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y116A8C.32 | Caenorhabditis elegans | slow growth | wormbase |
CELE_Y116A8C.32 | Caenorhabditis elegans | sterile | wormbase |
YLR116W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1122500 | Plasmodium berghei | Essential | plasmo |
TGME49_314860 | Toxoplasma gondii | Essentiality uncertain | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.